On the day of his last medical school exam, Danny Benson receives a letter from his fiancée Heather. In it, she writes that the engagement is off. Why? She is in London where she will catch the Magic Bus and travel overland to Kathmandu, Nepal.
With his plans shattered, Danny knows what he has to do: set out on a journey thousands of miles from home in search of her. Just one last conversation stands in the way of either rekindling their relationship or get the finality to move on with his life. When he inexplicably runs into Heather crossing continents, they spend the entire ride debating whether to stay together or break up forever.
Arriving in town and exhausted from their long bus trip, fate decides for them. Instead of resolution, their moment of truth happens when they collide with history.